AVDEEF, A: search on Z-Library

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1

Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 7.99 MB

english, 2018

2

The rise of PAMPA

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2005

Language:

english

File:

PDF, 917 KB

english, 2005

3

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Permeability-PAMPA

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

4

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H., Tsinman, Oksana, Sun, Na, Tsinman, Konstantin, Avdeef, Alex, Bergström, Christel A. S.

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 3.24 MB

english, 2010

5

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Year:

2020

File:

PDF, 1.27 MB

2020

6

Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

A. Avdeef, B. Testa

Journal:

Cellular and Molecular Life Sciences

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

7

pH-Metric log P. Part 1. Difference Plots for Determining Ion-Pair Octanol-Water Partition Coefficients of Multiprotic Substances

Journal:

Molecular Informatics

Year:

1992

Language:

english

File:

PDF, 559 KB

english, 1992

8

The Permeation of Amphoteric Drugs through Artificial Membranes − An in Combo Absorption Model Based on Paracellular and Transmembrane Permeability †

Tam, Kin Y., Avdeef, Alex, Tsinman, Oksana, Sun, Na

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

9

Bjerrum plots for the determination of systematic concentration errors in titration data

Avdeef, Alex., Kearney, Diane L., Brown, Jessica A., Chemotti, Alfred R.

Journal:

Analytical Chemistry

Year:

1982

Language:

english

File:

PDF, 630 KB

english, 1982

10

Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs

Journal:

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

11

pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

Alex Avdeef, Cynthia M. Berger, Charles Brownell

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

12

A PAMPA Study of the Permeability-Enhancing Effect of New Ceramide Analogues

Bálint Sinkó, József Kökösi, Alex Avdeef, Krisztina Takács-Novák

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 190 KB

english, 2009

13

Solubility of sparingly-soluble ionizable drugs

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 2.27 MB

english, 2007

14

Octanol−, Chloroform−, and Propylene Glycol Dipelargonat−Water Partitioning of Morphine-6-glucuronide and Other Related Opiates †

Avdeef, Alex, Barrett, David A., Shaw, P. Nicholas, Knaggs, Roger D., Davis, Stanley S.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 162 KB

english, 1996

15

Cocrystal solubility product analysis – Dual concentration-pH mass action model not dependent on explicit solubility equations

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 2.14 MB

english, 2017

16

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko, Kansy, Manfred, Artursson, Per, Avdeef, Alex, Bendels, Stefanie, Di, Li, Ecker, Gerhard F., Faller, Bernard, Fischer, Holger, Gerebtzoff, Grégori

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

17

PAMPA—a drug absorption in vitro model: 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

Marival Bermejo, Alex Avdeef, Ana Ruiz, Ricardo Nalda, Jeffrey A. Ruell, Oksana Tsinman, Isabel González, Carlos Fernández, Gloria Sánchez, Teresa M. Garrigues, Virginia Merino

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

18

PAMPA—a drug absorption in vitro model: 5. Unstirred water layer in iso-pH mapping assays and pKaflux—optimized design (pOD-PAMPA)

Jeffrey A Ruell, Konstantin L Tsinman, Alex Avdeef

Journal:

European Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

19

Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

Giulia Caron, Giuseppe Ermondi, Alessandro Damiano, Laura Novaroli, Oksana Tsinman, Jeffrey A. Ruell, Alex Avdeef

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 548 KB

english, 2004

20

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method

Alex Avdeef, Per Artursson, Sibylle Neuhoff, Lucia Lazorova, Johan Gråsjö, Staffan Tavelin

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 413 KB

english, 2005

21

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database

Journal:

Year:

2020

File:

PDF, 3.21 MB

2020

22

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Permeability: Blood-Brain Barrier

Year:

2012

Language:

english

File:

PDF, 757 KB

english, 2012

23

PH-metric log P 11. pKa determination of water-insoluble drugs in organic solvent–water mixtures

A Avdeef, K.J Box, J.E.A Comer, M Gilges, M Hadley, C Hibbert, W Patterson, K.Y Tam

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1999

Language:

english

File:

PDF, 429 KB

english, 1999

24

ChemInform Abstract: Estimating the Water Solubilities of Crystalline Compounds from Their Chemical Structures Alone.

James W. McFarland, Alex Avdeef, Cynthia M. Berger, Oleg A. Raevsky

Journal:

Year:

2001

File:

PDF, 25 KB

2001

25

In vitro trans-monolayer permeability calculations: often forgotten assumptions

Kuresh A Youdim, Alex Avdeef, N.Joan Abbott

Journal:

Drug Discovery Today

Year:

2003

Language:

english

File:

PDF, 104 KB

english, 2003

26

Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists

Manfred Kansy, Alex Avdeef, Holger Fischer

Journal:

Drug Discovery Today: Technologies

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

27

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Octanol-Water Partitioning

Year:

2012

Language:

english

File:

PDF, 3.78 MB

english, 2012

28

ChemInform Abstract: CRYSTAL AND MOLECULAR STRUCTURE OF TRIS(TROPOLONATO)MANGANESE(III), MN(O2C7H5)3, A HIGH-SPIN COMPLEX HAVING STRUCTURAL FEATURES CONSISTENT WITH JAHN-TELLER BEHAVIOR FOR TWO DISTINCT MNO6 CENTERS

AVDEEF, A., COSTAMAGNA, J. A., FACKLER, J. P. JUN.

Journal:

Chemischer Informationsdienst

Year:

1974

File:

PDF, 100 KB

1974

29

Absorption and Drug Development || References

Year:

2003

Language:

english

File:

PDF, 212 KB

english, 2003

30

Absorption and Drug Development (Solubility, Permeability, and Charge State) || p K a Determination

Year:

2012

Language:

english

File:

PDF, 7.49 MB

english, 2012

31

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Liposome-Water Partitioning

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

32

Structural trends of tris(acetylacetonate)-, tris(tropolonate)-, and other tris(bidentate ligand)-metal complexes. Additional comments on the trigonal twist and ligand-ligand repulsions in octahedral D3 bidentate ligand-metal complexes

Avdeef, A., Fackler, J. P.

Journal:

Inorganic Chemistry

Year:

1975

Language:

english

File:

PDF, 700 KB

english, 1975

33

PAMPA—a drug absorption in vitro model*111. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

AVDEEF, A, NIELSEN, P, TSINMAN, O

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

34

Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

Konstantin Tsinman, Alex Avdeef, Oksana Tsinman, Dmytro Voloboy

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

35

Membrane–Water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel

Beate I. Escher, Cindy Berger, Nadine Bramaz, Jung-Hwan Kwon, Manuela Richter, Oksana Tsinman, Alex Avdeef

Journal:

Environmental Toxicology and Chemistry

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

36

Absorption and Drug Development || Partitioning into Octanol

Year:

2003

Language:

english

File:

PDF, 257 KB

english, 2003

37

Absorption and Drug Development || Introduction

Year:

2003

Language:

english

File:

PDF, 55 KB

english, 2003

38

pH–metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the Octanol–Water partitioning of prostaglandins E1 and E2

Alex Avdeef, Karl J. Box, Krisztina Takács-Novák

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 833 KB

english, 1995

39

Biorelevant pKa (37 °C) predicted from the 2D structure of the molecule and its pKa at 25 °C

Na Sun, Alex Avdeef

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 701 KB

english, 2011

40

Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties

Gergely Völgyi, Gábor Vizserálek, Krisztina Takács-Novák, Alex Avdeef, Kin Y. Tam

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 374 KB

english, 2012

41

PAMPA—a drug absorption in vitro model: 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

Alex Avdeef, Per E Nielsen, Oksana Tsinman

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

42

Absorption and Drug Development (Solubility, Permeability, and Charge State) || Summary and Some Simple Approximations

Year:

2012

Language:

english

File:

PDF, 40 KB

english, 2012

43

Two isostructural actinide .pi. complexes. Crystal and molecular structure of bis(cyclooctatetraenyl)uranium(IV), U(C8H8)2, and bis(cyclooctatetraenyl)thorium(IV), Th(C8H8)2

Avdeef, Alex., Raymond, Kenneth N., Hodgson, Keith O., Zalkin, Allan.

Journal:

Inorganic Chemistry

Year:

1972

Language:

english

File:

PDF, 889 KB

english, 1972

44

Anomalous Solubility Behavior of Several Acidic Drugs

Journal:

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

45

A NewIn SituBrain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation

Alex Avdeef, Na Sun

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 415 KB

english, 2011

46

How Well Can the Caco-2/Madin−Darby Canine Kidney Models Predict Effective Human Jejunal Permeability? †

Avdeef, Alex, Tam, Kin Y.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.59 MB

english, 2010

47

Cadmium binding by biological ligands. 3. Five- and seven-cadmium binding in metallothionein: a detailed thermodynamic study

Avdeef, Alex, Zelazowski, Andrzej J., Garvey, Justine S.

Journal:

Inorganic Chemistry

Year:

1985

Language:

english

File:

PDF, 814 KB

english, 1985

48

ChemInform Abstract: STRUCTURAL TRENDS OF TRIS(ACETYLACETONATE)-, TRIS(TROPOLONATE)-, AND OTHER TRIS(BIDENTATE LIGAND)-METAL COMPLEXES. ADDITIONAL COMMENTS ON THE TRIGONAL TWIST AND LIGAND-LIGAND REPULSIONS IN ′OCTAHEDRAL′D3 BIDENTATE LIGAND-METAL COMPLEX

AVDEEF, A., FACKLER, J. P. JUN.

Journal:

Chemischer Informationsdienst

Year:

1975

File:

PDF, 104 KB

1975

49

Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling

Lucero-Borja, Diego, Subirats, Xavier, Barbas, Rafael, Prohens, Rafel, Avdeef, Alex, RÃ fols, Clara

Journal:

European Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 2.66 MB

2020

50

Ph-metric log P. 4. Comparison of partition coefficients determined by HPLC and potentiometric methods to literature values

Bryan Slater, Ann McCormack, Alex Avdeef, John E. A. Comer

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 437 KB

english, 1994

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